Article
Relationship of the serotonin transporter gene promoter polymorphism (5-HTTLPR) genotype and serotonin transporter binding to neural processing of negative emotional stimuli.
Journal of affective disorders - 15 Jan 2016
Schneck Noam, Miller Jeffrey M, Delorenzo Christine, Kikuchi Toshiaki, Sublette M Elizabeth, Oquendo Maria A, Mann J John, Parsey Ramin V
Abstract excerpt
BACKGROUND: The lower-expressing (S') alleles of the serotonin transporter (5-HTT) gene promoter polymorphism (5-HTTLPR) are linked to mood and anxiety related psychopathology. However, the specific neural mechanism through which these alleles may influence emotional and cognitive processing remains unknown. We examined the relationship between both 5-HTTLPR genotype and in vivo 5-HTT binding quantified via PET...
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