Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

5-HTT genotype effect on prefrontal-amygdala coupling differs between major depression and controls.

Psychopharmacology - 1 Aug 2009

Friedel Eva, Schlagenhauf Florian, Sterzer Philipp, Park Soyoung Q, Bermpohl Felix, Ströhle Andreas, Stoy Meline, Puls Imke, Hägele Claudia, Wrase Jana, Büchel Christian, Heinz Andreas

Abstract excerpt

RATIONALE: In major depression, prefrontal regulation of limbic brain areas may be a key mechanism that is impaired during the processing of affective information. This prefrontal-limbic interaction has been shown to be modulated by serotonin (5-HTT) genotype, indicating a higher risk for major depressive disorder (MDD) with increasing number of 5-HTT low-expression alleles. OBJECTIVE: Functional magnetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Affect
Share to Amygdala

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain Mapping

Share to Neural Pathways

Share to Photic Stimulation

Share to Prefrontal Cortex

Share to Statistics as Topic

Source

Identifiers

PMID: 19387615
DOI: 10.1007/s00213-009-1536-1

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

5-HTT genotype effect on prefrontal-amygdala coupling differs between major depression and controls.PMID 19387615Read ↗

Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter.Semantic proximity Read ↗

5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression.Semantic proximity Read ↗

Relationship of the serotonin transporter gene promoter polymorphism (5-HTTLPR) genotype and serotonin transporter binding to neural processing of negative emotional stimuli.Semantic proximity Read ↗

Reduced amygdala-prefrontal coupling in major depression: association with MAOA genotype and illness severity.Semantic proximity Read ↗

Imaging phenotypes of major depressive disorder: genetic correlates.Semantic proximity Read ↗

Serotonergic genes modulate amygdala activity in major depression.Semantic proximity Read ↗

Serotonin transporter polymorphism modulates N-back task performance and fMRI BOLD signal intensity in healthy women.Semantic proximity Read ↗

Modulation of amygdala response and connectivity in depression by serotonin transporter polymorphism and diagnosis.Semantic proximity Read ↗

Catechol-O-methyltransferase Val(108/158)Met polymorphism affects fronto-limbic connectivity during emotional processing in bipolar disorderSemantic proximity Read ↗

The 5-HTTLPR Polymorphism Affects Network-Based Functional Connectivity in the Visual-Limbic System in Healthy Adults.Semantic proximity Read ↗

Genetic variation in the serotonin transporter modulates neural system-wide response to fearful faces.Semantic proximity Read ↗

Cortico-limbic functional connectivity mediates the effect of early life stress on suicidality in bipolar depressed 5-HTTLPR*s carriers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.