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Article

Impact of 5-HTTLPR on SSRI serotonin transporter blockade during emotion regulation: A preliminary fMRI study.

Journal of affective disorders - 15 May 2016

Outhred Tim, Das Pritha, Dobson-Stone Carol, Felmingham Kim L, Bryant Richard A, Nathan Pradeep J, Malhi Gin S, Kemp Andrew H

Abstract excerpt

BACKGROUND: The short ('S') allele of the serotonin transporter (5-HTT)-linked polymorphic region (5-HTTLPR) is associated with increased negative emotion processing bias, and this polymorphism moderates acute effects of selective serotonin reuptake inhibitor (SSRI) treatment. In this preliminary study, we explore the moderating effect of 5-HTTLPR on the impact of the SSRI, escitalopram during emotion regulation...

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Source

Identifiers

PMID: 26896742
DOI: 10.1016/j.jad.2016.02.019

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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