Serotonin transporter genotype modulates the association between depressive symptoms and amygdala activity among psychiatrically healthy adults.

doi:10.1016/j.pscychresns.2011.03.003

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Serotonin transporter genotype modulates the association between depressive symptoms and amygdala activity among psychiatrically healthy adults.

Psychiatry research - 30 Sept 2011

Gillihan Seth J, Rao Hengyi, Brennan Lauretta, Wang Danny J J, Detre John A, Sankoorikal Geena Mary V, Brodkin Edward S, Farah Martha J

Abstract excerpt

Recent attempts to understand the biological bases of depression vulnerability have revealed that both the short allele of the serotonin transporter-linked polymorphic region (5-HTTLPR) and activity in the amygdala are associated with depression. Other studies have reported amygdala hyperactivity associated with the 5-HTTLPR short allele, linking the genetic and neuroimaging lines of research and suggesting a...

Topics

Adolescent
Adult
Amygdala
Brain Mapping
Depression
Female
Functional Laterality
Genotype
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Oxygen

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Personality Assessment

Polymorphism, Genetic

Psychiatric Status Rating Scales

Serotonin Plasma Membrane Transport Proteins

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 21764567
DOI: 10.1016/j.pscychresns.2011.03.003
PMCID: PMC3156965

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.