Article
Calcineurin homologous proteins regulate the membrane localization and activity of sodium/proton exchangers in C. elegans.
American journal of physiology. Cell physiology - 1 Feb 2016
Allman Erik, Wang Qian, Walker Rachel L, Austen Molly, Peters Maureen A, Nehrke Keith
Abstract excerpt
Calcineurin B homologous proteins (CHP) are N-myristoylated, EF-hand Ca(2+)-binding proteins that bind to and regulate Na(+)/H(+) exchangers, which occurs through a variety of mechanisms whose relative significance is incompletely understood. Like mammals, Caenorhabditis elegans has three CHP paralogs, but unlike mammals, worms can survive CHP loss-of-function. However, mutants for the CHP ortholog PBO-1 are...
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