Article
The C. elegans homologs of nephrocystin-1 and nephrocystin-4 are cilia transition zone proteins involved in chemosensory perception.
Journal of cell science - 1 Dec 2005
Winkelbauer Marlene E, Schafer Jenny C, Haycraft Courtney J, Swoboda Peter, Yoder Bradley K
Abstract excerpt
Nephronophthisis (NPH) is a cystic kidney disorder that causes end-stage renal failure in children. Five nephrocystin (nephrocystin-1 to nephrocystin-5) genes, whose function is disrupted in NPH patients, have been identified and data indicate they form a complex at cell junctions and focal adhesions. More recently, the nephrocystin proteins have also been identified in cilia, as have multiple other cystic kidney...
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