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Article

The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure.

The Journal of cell biology - 10 Mar 2008

Jauregui Andrew R, Nguyen Ken C Q, Hall David H, Barr Maureen M

Abstract excerpt

Nephronophthisis (NPHP) is the most common genetic cause of end-stage renal disease in children and young adults. In Chlamydomonas reinhardtii, Caenorhabditis elegans, and mammals, the NPHP1 and NPHP4 gene products nephrocystin-1 and nephrocystin-4 localize to basal bodies or ciliary transition zones (TZs), but their function in this location remains unknown. We show here that loss of C. elegans NPHP-1 and NPHP-4...

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Source

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Identifiers

PMID: 18316409
DOI: 10.1083/jcb.200707090
PMCID: PMC2265406

Genes

NPHP1
NPHP4

Provenance

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