Article
Functional and phenotypic relevance of differentially expressed proteins in calcineurin mutants of Caenorhabditis elegans.
Proteomics - 1 Feb 2006
Ahn Do-Hwan, Singaravelu Gunasekaran, Lee Sooung, Ahnn Joohong, Shim Yhong-Hee
Abstract excerpt
Calcineurin is a heterodimeric serine/threonine protein phosphatase, important for many cellular processes such as T-cell regulation, cardiac hypertrophy and kidney development. We previously reported the characterization of Caenorhabditis elegans calcineurin mutants as providing a simple but excellent genetic model system for studying in vivo functions of calcineurin. Calcineurin loss-of-function mutants,...
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