Article
Extensive HLA-driven viral diversity following a narrow-source HIV-1 outbreak in rural China.
Blood - 7 Jul 2011
Dong Tao, Zhang Yonghong, Xu Ke Yi, Yan Huiping, James Ian, Peng Yanchun, Blais Marie-Eve, Gaudieri Silvana, Chen Xinyue, Lun Wenhui, Wu Hao, Qu Wen Yan, Rostron Tim, Li Ning, Mao Yu, Mallal Simon, Xu Xiaoning, McMichael Andrew, John Mina, Rowland-Jones Sarah L
Abstract excerpt
Obstacles to developing an HIV-1 vaccine include extensive viral diversity and lack of correlates of protective immunity. High mutation rates allow HIV-1 to adapt rapidly to selective forces such as antiretroviral therapy and immune pressure, including HIV-1-specific CTLs that select viral variants which escape T-cell recognition. Multiple factors contribute to HIV-1 diversity, making it difficult to disentangle...
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