Article
Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels.
Genomics - 1 Nov 2005
Cervino Alessandra C, Li Guoya, Edwards Steve, Zhu Jun, Laurie Cathy, Tokiwa George, Lum Pek Yee, Wang Susanna, Castellani Lawrence W, Castellini Lawrence W, Lusis Aldons J, Carlson Sonia, Sachs Alan B, Schadt Eric E
Abstract excerpt
The use of inbred strains of mice to dissect the genetic complexity of common diseases offers a viable alternative to human studies, given the control over experimental parameters that can be exercised. Central to efforts to map susceptibility loci for common diseases in mice is a comprehensive map of DNA variation among the common inbred strains of mice. Here we present one of the most comprehensive...
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