Article
Quantitative trait loci analysis for the differences in susceptibility to atherosclerosis and diabetes between inbred mouse strains C57BL/6J and C57BLKS/J.
Journal of lipid research - 1 Jul 1999
Mu J L, Naggert J K, Svenson K L, Collin G B, Kim J H, McFarland C, Nishina P M, Levine D M, Williams K J, Paigen B
Abstract excerpt
Mice from the inbred strain C57BLKS/J (BKS) exhibit increased susceptibility to both diabetes and atherosclerosis compared to C57BL/6J (B6) mice. To determine whether the differences in diabetes and atherosclerosis are related, we carried out a cross between B6-db/db and BKS. We selected 99 female F2-db/db progeny, tested the progeny for plasma lipids, plasma glucose, and fatty-streak lesions, and used...
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