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Article

Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis.

Proceedings of the National Academy of Sciences of the United States of America - 24 Nov 2015

Hwang Seong-Hye, Jung Seung-Hyun, Lee Saseong, Choi Susanna, Yoo Seung-Ah, Park Ji-Hwan, Hwang Daehee, Shim Seung Cheol, Sabbagh Laurent, Kim Ki-Jo, Park Sung Hwan, Cho Chul-Soo, Kim Bong-Sung, Leng Lin, Montgomery Ruth R, Bucala Richard, Chung Yeun-Jun, Kim Wan-Uk

Abstract excerpt

Copy number variations (CNVs) have been implicated in human diseases. However, it remains unclear how they affect immune dysfunction and autoimmune diseases, including rheumatoid arthritis (RA). Here, we identified a novel leukocyte-specific protein 1 (LSP1) deletion variant for RA susceptibility located in 11p15.5. We replicated that the copy number of LSP1 gene is significantly lower in patients with RA, which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26554018
DOI: 10.1073/pnas.1514152112
PMCID: PMC4664344

Genes

LSP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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