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CLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunity

20 Jun 2025

Abstract excerpt

Pathogenic CD4 T cells drive autoimmunity in diseases such as multiple sclerosis (MS) and inflammatory bowel disease (IBD). Through a forward genetic screen, we identified chloride nucleotide-sensitive channel 1A (CLNS1A) as a key regulator of inflammation in the experimental autoimmune encephalomyelitis (EAE) model of MS. CLNS1A is expressed in several subsets of CD4 T cells, including pathogenic T helper 17 (pT...

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PMID: 40540585
DOI: 10.1126/sciimmunol.adq8860

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