Article

LAT1 enables T cell activation under inflammatory conditions: a new therapeutic target for rheumatoid arthritis

2022-12-20

Abstract excerpt

<h4>Objective</h4> To assess the L-type amino acid transporter-1 (LAT1) as a possible therapeutic target for rheumatoid arthritis (RA). <h4>Methods</h4> Synovial LAT1 expression was monitored by immunohistochemistry and transcriptomic datasets. The contribution of LAT1 to gene expression and immune synapse formation was assessed by RNA-sequencing and total internal reflection fluorescent (TIRF) microscopy, respe...

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Literature Corpus work: 1d67c860-1bb7-5808-bb02-1dcd1eeb545d
DOI: 10.1101/2022.12.20.520910

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