Article
Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load.
Proceedings of the National Academy of Sciences of the United States of America - 24 Nov 2015
McLaren Paul J, Coulonges Cedric, Bartha István, Lenz Tobias L, Deutsch Aaron J, Bashirova Arman, Buchbinder Susan, Carrington Mary N, Cossarizza Andrea, Dalmau Judith, De Luca Andrea, Goedert James J, Gurdasani Deepti, Haas David W, Herbeck Joshua T, Johnson Eric O, Kirk Gregory D, Lambotte Olivier, Luo Ma, Mallal Simon, van Manen Daniëlle, Martinez-Picado Javier, Meyer Laurence, Miro José M, Mullins James I, Obel Niels, Poli Guido, Sandhu Manjinder S, Schuitemaker Hanneke, Shea Patrick R, Theodorou Ioannis, Walker Bruce D, Weintrob Amy C, Winkler Cheryl A, Wolinsky Steven M, Raychaudhuri Soumya, Goldstein David B, Telenti Amalio, de Bakker Paul I W, Zagury Jean-François, Fellay Jacques
Abstract excerpt
Previous genome-wide association studies (GWAS) of HIV-1-infected populations have been underpowered to detect common variants with moderate impact on disease outcome and have not assessed the phenotypic variance explained by genome-wide additive effects. By combining the majority of available genome-wide genotyping data in HIV-infected populations, we tested for association between ∼8 million variants and viral...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.