Article
A whole-genome association study of major determinants for host control of HIV-1.
Science (New York, N.Y.) - 17 Aug 2007
Fellay Jacques, Shianna Kevin V, Ge Dongliang, Colombo Sara, Ledergerber Bruno, Weale Mike, Zhang Kunlin, Gumbs Curtis, Castagna Antonella, Cossarizza Andrea, Cozzi-Lepri Alessandro, De Luca Andrea, Easterbrook Philippa, Francioli Patrick, Mallal Simon, Martinez-Picado Javier, Miro José M, Obel Niels, Smith Jason P, Wyniger Josiane, Descombes Patrick, Antonarakis Stylianos E, Letvin Norman L, McMichael Andrew J, Haynes Barton F, Telenti Amalio, Goldstein David B
Abstract excerpt
Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous...
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