Article
Common genetic variation and the control of HIV-1 in humans.
PLoS genetics - 1 Dec 2009
Fellay Jacques, Ge Dongliang, Shianna Kevin V, Colombo Sara, Ledergerber Bruno, Cirulli Elizabeth T, Urban Thomas J, Zhang Kunlin, Gumbs Curtis E, Smith Jason P, Castagna Antonella, Cozzi-Lepri Alessandro, De Luca Andrea, Easterbrook Philippa, Günthard Huldrych F, Mallal Simon, Mussini Cristina, Dalmau Judith, Martinez-Picado Javier, Miro José M, Obel Niels, Wolinsky Steven M, Martinson Jeremy J, Detels Roger, Margolick Joseph B, Jacobson Lisa P, Descombes Patrick, Antonarakis Stylianos E, Beckmann Jacques S, O'Brien Stephen J, Letvin Norman L, McMichael Andrew J, Haynes Barton F, Carrington Mary, Feng Sheng, Telenti Amalio, Goldstein David B
Abstract excerpt
To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further...
Topics
- Adult
- Alleles
- Disease Progression
- Female
- Genetic Variation
- Genotype
- HIV Infections