Article
Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population.
AIDS (London, England) - 20 Feb 2011
Petrovski Slavé, Fellay Jacques, Shianna Kevin V, Carpenetti Nicole, Kumwenda Johnstone, Kamanga Gift, Kamwendo Deborah D, Letvin Norman L, McMichael Andrew J, Haynes Barton F, Cohen Myron S, Goldstein David B
Abstract excerpt
OBJECTIVE: To date, CCR5 variants remain the only human genetic factors to be confirmed to impact HIV-1 acquisition. However, protective CCR5 variants are largely absent in African populations, in which sporadic resistance to HIV-1 infection is still unexplained. We investigated whether common genetic variants associate with HIV-1 susceptibility in Africans. METHODS: We performed a genome-wide association study...
Topics
- Adolescent
- Adult
- Black People
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- HIV Infections
- HIV-1
- Humans
- Malawi