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Article

Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme.

Nature - 10 Dec 2009

Qi Yan, Spong Marie C, Nam Kwangho, Banerjee Anirban, Jiralerspong Sao, Karplus Martin, Verdine Gregory L

Abstract excerpt

How living systems detect the presence of genotoxic damage embedded in a million-fold excess of undamaged DNA is an unresolved question in biology. Here we have captured and structurally elucidated a base-excision DNA repair enzyme, MutM, at the stage of initial encounter with a damaged nucleobase, 8-oxoguanine (oxoG), nested within a DNA duplex. Three structures of intrahelical oxoG-encounter complexes are...

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Identifiers

PMID: 20010681
DOI: 10.1038/nature08561
PMCID: PMC2951314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme.PMID 20010681Read ↗

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