Article
Mutation of the gene encoding the ribonuclease P RNA in the hyperthermophilic archaeon Thermococcus kodakarensis causes decreased growth rate and impaired processing of tRNA precursors.
Biochemical and biophysical research communications - 25 Dec 2015
Ueda Toshifumi, Ishino Sonoko, Suematsu Kotaro, Nakashima Takashi, Kakuta Yoshimitsu, Kawarabayasi Yutaka, Ishino Yoshizumi, Kimura Makoto
Abstract excerpt
Ribonuclease P (RNase P) catalyzes the processing of 5' leader sequences of tRNA precursors in all three phylogenetic domains. RNase P also plays an essential role in non-tRNA biogenesis in bacterial and eukaryotic cells. For archaeal RNase Ps, additional functions, however, remain poorly understood. To gain insight into the biological function of archaeal RNase Ps in vivo, we prepared archaeal mutants KUWΔP3,...
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