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Article

Analysis of the functional modules of the tRNA 3' endonuclease (tRNase Z).

The Journal of biological chemistry - 21 Oct 2005

Späth Bettina, Kirchner Silvia, Vogel Andreas, Schubert Sylvia, Meinlschmidt Petra, Aymanns Simone, Nezzar Jamel, Marchfelder Anita

Abstract excerpt

tRNA 3' processing is one of the essential steps during tRNA maturation. The tRNA 3'-processing endonuclease tRNase Z was only recently isolated, and its functional domains have not been identified so far. We performed an extensive mutational study to identify amino acids and regions involved in dimerization, tRNA binding, and catalytic activity. 29 deletion and point variants of the tRNase Z enzyme were...

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PMID: 16118225
DOI: 10.1074/jbc.M506418200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Analysis of the functional modules of the tRNA 3' endonuclease (tRNase Z).PMID 16118225Read ↗

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tRNA 3' end maturation in archaea has eukaryotic features: the RNase Z from Haloferax volcanii.Semantic proximity Read ↗

Metal requirements and phosphodiesterase activity of tRNase Z enzymes.Semantic proximity Read ↗

The flexible arm of tRNase Z is not essential for pre-tRNA binding but affects cleavage site selection.Semantic proximity Read ↗

Effect of changes in the flexible arm on tRNase Z processing kinetics.Semantic proximity Read ↗

U-Insertion/Deletion mRNA-Editing Holoenzyme: Definition in SightSemantic proximity Read ↗

SLFN-generated 3′-truncated tRNA <sup>Leu</sup> or tRNA <sup>Ser</sup> together with tRNase Z <sup>L</sup> works as a sequence-specific RNA cutterSemantic proximity Read ↗

Pathogenesis-related mutations in the T-loops of human mitochondrial tRNAs affect 3' end processing and tRNA structure.Semantic proximity Read ↗

Residues in the conserved His domain of fruit fly tRNase Z that function in catalysis are not involved in substrate recognition or binding.Semantic proximity Read ↗

Enzymatic formation of modified nucleosides in tRNA: dependence on tRNA architecture.Semantic proximity Read ↗

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