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Article

Genome-wide search for yeast RNase P substrates reveals role in maturation of intron-encoded box C/D small nucleolar RNAs.

Proceedings of the National Academy of Sciences of the United States of America - 26 Aug 2008

Coughlin Daniel J, Pleiss Jeffrey A, Walker Scott C, Whitworth Gregg B, Engelke David R

Abstract excerpt

Ribonuclease P (RNase P) is an essential endonuclease responsible for the 5'-end maturation of precursor tRNAs. Bacterial RNase P also processes precursor 4.5S RNA, tmRNA, 30S preribosomal RNA, and several reported protein-coding RNAs. Eukaryotic nuclear RNase P is far more complex than in the bacterial form, employing multiple essential protein subunits in addition to the catalytic RNA subunit. RNomic studies...

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Identifiers

PMID: 18713869
DOI: 10.1073/pnas.0801906105
PMCID: PMC2527892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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