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Article

Structural insights into RNA unwinding and degradation by RNase R.

Nucleic acids research - 16 Nov 2017

Chu Lee-Ya, Hsieh Tung-Ju, Golzarroshan Bagher, Chen Yi-Ping, Agrawal Sashank, Yuan Hanna S

Abstract excerpt

RNase R is a conserved exoribonuclease in the RNase II family that primarily participates in RNA decay in all kingdoms of life. RNase R degrades duplex RNA with a 3' overhang, suggesting that it has RNA unwinding activity in addition to its 3'-to-5' exoribonuclease activity. However, how RNase R coordinates RNA binding with unwinding to degrade RNA remains elusive. Here, we report the crystal structure of a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29036353
DOI: 10.1093/nar/gkx880
PMCID: PMC5714204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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