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Article

Identification of the amino acid residues essential for proteolytic activity in an archaeal signal peptide peptidase.

The Journal of biological chemistry - 14 Apr 2006

Matsumi Rie, Atomi Haruyuki, Imanaka Tadayuki

Abstract excerpt

Signal peptide peptidases (SPPs) are enzymes involved in the initial degradation of signal peptides after they are released from the precursor proteins by signal peptidases. In contrast to the eukaryotic enzymes that are aspartate peptidases, the catalytic mechanisms of prokaryotic SPPs had not been known. In this study on the SPP from the hyperthermophilic archaeon Thermococcus kodakaraensis (SppA(Tk)), we have...

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PMID: 16484219
DOI: 10.1074/jbc.M513754200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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