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Article

Generation of pre-tRNAs from polycistronic operons is the essential function of RNase P in Escherichia coli.

Nucleic acids research - 18 Mar 2020

Mohanty Bijoy K, Agrawal Ankit, Kushner Sidney R

Abstract excerpt

Ribonuclease P (RNase P) is essential for the 5'-end maturation of tRNAs in all kingdoms of life. In Escherichia coli, temperature sensitive mutations in either its protein (rnpA49) and or RNA (rnpB709) subunits lead to inviability at nonpermissive temperatures. Using the rnpA49 temperature sensitive allele, which encodes a partially defective RNase P at the permissive temperature, we show here for the first time...

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Identifiers

PMID: 31993626
DOI: 10.1093/nar/gkz1188
PMCID: PMC7049720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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