Article
Minor changes largely restore catalytic activity of archaeal RNase P RNA from Methanothermobacter thermoautotrophicus.
Nucleic acids research - 1 Jan 2009
Li Dan, Willkomm Dagmar K, Hartmann Roland K
Abstract excerpt
The increased protein proportion of archaeal and eukaryal ribonuclease (RNase) P holoenzymes parallels a vast decrease in the catalytic activity of their RNA subunits (P RNAs) alone. We show that a few mutations toward the bacterial P RNA consensus substantially activate the catalytic (C-) domain of archaeal P RNA from Methanothermobacter, in the absence and presence of the bacterial RNase P protein. Large...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.