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CYP2D6 copy number distribution in the US population

7 Nov 2015

Abstract excerpt

The cytochrome P450 2D6 (CYP2D6) gene is perhaps the most well characterized gene involved in drug metabolism and is known to have both gene duplication and deletion variants that are inheritable and stable. In a set of over 30,000 deidentified clinical samples we found that 12.6% of all patients tested had zero, one, or three or more copies of the CYP2D6 gene. On the basis of the combined frequency and impact of...

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PMID: 26551314
DOI: 10.1097/fpc.0000000000000188

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