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Article

Prevalence of CYP2D6 structural variation in large retrospective study.

Pharmacogenetics and genomics - 1 Jun 2024

Frear Samantha, Sherman Ashley, Rule Don, Marcath Lauren Ann

Abstract excerpt

CYP2D6 is a highly polymorphic gene with clinically important structural variations. Commonly, only exon 9 is assayed on clinical pharmacogenomics panels, as it allows for accurate functional characterization even in the presence of a CYP2D6::CYP2D7 conversion. However, this method does not capture CYP2D7::CYP2D6 (CYP2D6*13) conversions, possibly leading to inaccurate phenotype assignment. The study's purpose was...

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Identifiers

PMID: 38372405
DOI: 10.1097/FPC.0000000000000525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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