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Article

CYP2D6 genotyping for functional-gene dosage analysis by allele copy number detection.

Clinical chemistry - 1 Aug 2009

Hosono Naoya, Kato Mamoru, Kiyotani Kazuma, Mushiroda Taisei, Takata Sadaaki, Sato Hiroko, Amitani Hanae, Tsuchiya Yumiko, Yamazaki Keiko, Tsunoda Tatsuhiko, Zembutsu Hitoshi, Nakamura Yusuke, Kubo Michiaki

Abstract excerpt

BACKGROUND: Cytochrome P450 2D6 (CYP2D6), one of the most important drug-metabolizing enzymes, has been reported to possess variation in the encoding CYP2D6 gene (cytochrome P450, family 2, subfamily D, polypeptide 6) that affects enzymatic activity. For the pharmacogenetic study of CYP2D6, accurate measurement of the dosage of the functional gene is essential; however, current genotyping techniques are...

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PMID: 19541866
DOI: 10.1373/clinchem.2009.123620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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