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Article

A novel simple method for determining CYP2D6 gene copy number and identifying allele(s) with duplication/multiplication.

PloS one - 1 Jan 2015

Langaee Taimour, Hamadeh Issam, Chapman Arlene B, Gums John G, Johnson Julie A

Abstract excerpt

BACKGROUND: Cytochrome P450 2D6 (CYP2D6) gene duplication and multiplication can result in ultrarapid drug metabolism and therapeutic failure or excessive response in patients. Long range polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP) and sequencing are usually used for genotyping CYP2D6 duplication/multiplications and identification, but are labor intensive, time consuming, and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25625348
DOI: 10.1371/journal.pone.0113808
PMCID: PMC4308104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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