Article
Allelic distributions of CYP2D6 gene copy number variation in the Eastern Han Chinese population.
Acta pharmacologica Sinica - 1 Feb 2007
Sheng Hai-hui, Zeng Ai-ping, Zhu Wen-xiang, Zhu Ren-fang, Li Hong-mei, Zhu Zhi-dong, Qin Ying, Jin Wei, Liu Yan, Du Yun-lan, Sun Jian, Xiao Hua-sheng
Abstract excerpt
AIM: The human cytochrome P450 2D6 (CYP2D6) gene copy number variation, involving CYP2D6 gene deletion (CYP2D6*5) and duplication or multiduplication (CYP2D6*xN), can result in reduced or increased metabolism of many clinically used drugs. The identification of CYP2D6*5 and CYP2D6*xN and the investigation of their allelic distributions in ethnic populations can be important in determining the right drug and...
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