Candidate DNA repair susceptibility genes identified by exome sequencing in high-risk pancreatic cancer.

doi:10.1016/j.canlet.2015.10.030

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Article

Candidate DNA repair susceptibility genes identified by exome sequencing in high-risk pancreatic cancer.

Cancer letters - 28 Jan 2016

Smith Alyssa L, Alirezaie Najmeh, Connor Ashton, Chan-Seng-Yue Michelle, Grant Robert, Selander Iris, Bascuñana Claire, Borgida Ayelet, Hall Anita, Whelan Thomas, Holter Spring, McPherson Treasa, Cleary Sean, Petersen Gloria M, Omeroglu Atilla, Saloustros Emmanouil, McPherson John, Stein Lincoln D, Foulkes William D, Majewski Jacek, Gallinger Steven, Zogopoulos George

Abstract excerpt

The genetic basis underlying the majority of hereditary pancreatic adenocarcinoma (PC) is unknown. Since DNA repair genes are widely implicated in gastrointestinal malignancies, including PC, we hypothesized that there are novel DNA repair PC susceptibility genes. As germline DNA repair gene mutations may lead to PC subtypes with selective therapeutic responses, we also hypothesized that there is an overall...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 26546047
DOI: 10.1016/j.canlet.2015.10.030
PMCID: PMC5725760

Genes

FAN1
NEK1
RHNO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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