Article
Whole genome sequencing identifies rare genetic variants in familial pancreatic cancer patients.
Annals of human genetics - 1 Jul 2022
Tan Ming, Brusgaard Klaus, Gerdes Anne-Marie, Larsen Martin Jakob, Mortensen Michael Bau, Detlefsen Sönke, de Muckadell Ove B Schaffalitzky, Joergensen Maiken Thyregod
Abstract excerpt
Pancreatic ductal adenocarcinoma (PDAC) represents one of the most lethal malignancies with very high mortality and short survival time. About 5-10% of the PDAC patients have a familial predisposition to the disease designated as familial pancreatic cancer (FPC), suggesting genetic modulation of FPC pathogenesis. It is estimated that currently identified sequence variants account for less than 20% of the genetic...
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