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Article

Exome-Wide Association Study of Pancreatic Cancer Risk.

Gastroenterology - 1 Feb 2018

Grant Robert C, Denroche Robert E, Borgida Ayelet, Virtanen Carl, Cook Natalie, Smith Alyssa L, Connor Ashton A, Wilson Julie M, Peterson Gloria, Roberts Nicholas J, Klein Alison P, Grimmond Sean M, Biankin Andrew, Cleary Sean, Moore Malcolm, Lemire Mathieu, Zogopoulos George, Stein Lincoln, Gallinger Steven

Abstract excerpt

We conducted a case-control exome-wide association study to discover germline variants in coding regions that affect risk for pancreatic cancer, combining data from 5 studies. We analyzed exome and genome sequencing data from 437 patients with pancreatic cancer (cases) and 1922 individuals not known to have cancer (controls). In the primary analysis, BRCA2 had the strongest enrichment for rare inactivating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29074453
DOI: 10.1053/j.gastro.2017.10.015
PMCID: PMC5811358

Genes

BRCA2
CHST6
EPHA1
FGFR3
UHMK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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