Article
The spectrum of genetic variants in hereditary pancreatic cancer includes Fanconi anemia genes.
Familial cancer - 1 Apr 2018
Slavin Thomas P, Neuhausen Susan L, Nehoray Bita, Niell-Swiller Mariana, Solomon Ilana, Rybak Christina, Blazer Kathleen, Adamson Aaron, Yang Kai, Sand Sharon, Guerrero-Llamas Nancy, Castillo Danielle, Herzog Josef, Wu Xiwei, Tao Shu, Raja Shivali, Chung Vincent, Singh Gagandeep, Nadesan Sue, Brown Sandra, Cruz-Correa Marcia, Petersen Gloria M, Weitzel Jeffrey
Abstract excerpt
Approximately 5-10% of all pancreatic cancer patients carry a predisposing mutation in a known susceptibility gene. Since >90% of patients present with late stage disease, it is crucial to identify high risk individuals who may be amenable to early detection or other prevention. To explore the spectrum of hereditary pancreatic cancer susceptibility, we evaluated germline DNA from pancreatic cancer participants...
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