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Article

Germline Variants and Risk for Pancreatic Cancer: A Systematic Review and Emerging Concepts.

Pancreas - 1 Sept 2018

Zhan Wei, Shelton Celeste A, Greer Phil J, Brand Randall E, Whitcomb David C

Abstract excerpt

Pancreatic cancer requires many genetic mutations. Combinations of underlying germline variants and environmental factors may increase the risk of cancer and accelerate the oncogenic process. We systematically reviewed, annotated, and classified previously reported pancreatic cancer-associated germline variants in established risk genes. Variants were scored using multiple criteria and binned by evidence for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30113427
DOI: 10.1097/MPA.0000000000001136
PMCID: PMC6097243

Genes

APC
ATM
BRCA1
BRCA2
CFTR
CHEK2
MLH1
MSH2
NBN
PALB2
PALLD
PRSS1
SPINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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