Article
Genetic characterization of two gain-of-function alleles of the effector caspase DrICE in Drosophila.
Cell death and differentiation - 1 Apr 2016
Wu Y, Lindblad J L, Garnett J, Kamber Kaya H E, Xu D, Zhao Y, Flores E R, Hardy J, Bergmann A
Abstract excerpt
Caspases are the executioners of apoptosis. Although much is known about their physiological roles and structures, detailed analyses of missense mutations of caspases are lacking. As mutations within caspases are identified in various human diseases, the study of caspase mutants will help to elucidate how caspases interact with other components of the apoptosis pathway and how they may contribute to disease....
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