Article
The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process.
Development (Cambridge, England) - 1 Sept 2006
Muro Israel, Berry Deborah L, Huh Jun R, Chen Chun Hong, Huang Haixia, Yoo Soon Ji, Guo Ming, Baehrecke Eric H, Hay Bruce A
Abstract excerpt
Caspase family proteases play important roles in the regulation of apoptotic cell death. Initiator caspases are activated in response to death stimuli, and they transduce and amplify these signals by cleaving and thereby activating effector caspases. In Drosophila, the initiator caspase Nc (previously Dronc) cleaves and activates two short-prodomain caspases, Dcp-1 and Ice (previously Drice), suggesting these as...
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