Structure and activation mechanism of the Drosophila initiator caspase Dronc.

doi:10.1074/jbc.M513232200

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Article

Structure and activation mechanism of the Drosophila initiator caspase Dronc.

The Journal of biological chemistry - 31 Mar 2006

Yan Nieng, Huh Jun R, Schirf Virgil, Demeler Borries, Hay Bruce A, Shi Yigong

Abstract excerpt

Activation of an initiator caspase is essential to the execution of apoptosis. The molecular mechanisms by which initiator caspases are activated remain poorly understood. Here we demonstrate that the autocatalytic cleavage of Dronc, an important initiator caspase in Drosophila, results in a drastic enhancement of its catalytic activity in vitro. The autocleaved Dronc forms a homodimer, whereas the uncleaved...

Topics

Amino Acid Sequence
Animals
Binding Sites
Caspases
Catalysis
Chromatography, Gel
Conserved Sequence
Crystallography, X-Ray
Dimerization
Drosophila
Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Electrophoresis, Polyacrylamide Gel

Enzyme Activation

Enzyme Precursors

Immunohistochemistry

Kinetics

Models, Biological

Models, Molecular

Source

Open in PubMed

Identifiers

PMID: 16446367
DOI: 10.1074/jbc.M513232200

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