Article
A biochemical analysis of the activation of the Drosophila caspase DRONC.
Cell death and differentiation - 1 Mar 2008
Dorstyn L, Kumar S
Abstract excerpt
The activation of caspases is the principal event in the execution of apoptosis. Initiator caspases are activated through an autocatalytic mechanism often involving dimerisation or oligomerisation. In Drosophila, the only initiator caspase DRONC, is tightly inhibited by DIAP1 and removal of DIAP1 permits activation of DRONC by the Drosophila Apaf-1-related killer, ARK. ARK is proposed to facilitate DRONC...
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