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Article

The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila.

Developmental cell - 1 Dec 2004

Chew Su Kit, Akdemir Fatih, Chen Po, Lu Wan-Jin, Mills Kathryn, Daish Tasman, Kumar Sharad, Rodriguez Antony, Abrams John M

Abstract excerpt

Among the seven caspases encoded in the fly genome, only dronc contains a caspase recruitment domain. To assess the function of this gene in development, we produced a null mutation in dronc. Animals lacking zygotic dronc are defective for programmed cell death (PCD) and arrest as early pupae. These mutants present a range of defects, including extensive hyperplasia of hematopoietic tissues, supernumerary...

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Identifiers

PMID: 15572131
DOI: 10.1016/j.devcel.2004.09.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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