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Article

Activation of sterol regulatory element-binding protein by the caspase Drice in Drosophila larvae.

The Journal of biological chemistry - 10 Apr 2009

Amarneh Bilal, Matthews Krista A, Rawson Robert B

Abstract excerpt

During larval development in Drosophila melanogaster, transcriptional activation of target genes by sterol regulatory element-binding protein (dSREBP) is essential for survival. In all cases studied to date, activation of SREBPs requires sequential proteolysis of the membrane-bound precursor by site-1 protease (S1P) and site-2 protease (S2P). Cleavage by S2P, within the first membrane-spanning helix of SREBP,...

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Identifiers

PMID: 19224859
DOI: 10.1074/jbc.M900346200
PMCID: PMC2665088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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