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Article

The Drosophila caspase DRONC is regulated by DIAP1.

The EMBO journal - 15 Feb 2000

Meier P, Silke J, Leevers S J, Evan G I

Abstract excerpt

We have isolated the recently identified Drosophila caspase DRONC through its interaction with the effector caspase drICE. Ectopic expression of DRONC induces cell death in Schizosaccharomyces pombe, mammalian fibroblasts and the developing Drosophila eye. The caspase inhibitor p35 fails to rescue DRONC-induced cell death in vivo and is not cleaved by DRONC in vitro, making DRONC the first identified...

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Identifiers

PMID: 10675329
DOI: 10.1093/emboj/19.4.598
PMCID: PMC305598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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