Article
Tissue transglutaminase: from biological glue to cell survival cues.
Frontiers in bioscience : a journal and virtual library - 1 Jan 2006
Mehta Kapil, Fok Jansina Y, Mangala Lingegowda S
Abstract excerpt
Tissue transglutaminase (TG2, EC 2.3.2.13) is a ubiquitous enzyme that catalyzes Ca2+-dependent post-translational modification of proteins by inserting highly stable (epsilon-[gamma-glutamyl] lysine) isopeptide bonds or by conjugating polyamines at selected peptide-bound glutamine residues. The TG2-catalyzed cross-linked products (generally high molecular mass scaffold of proteins) are of great physiological...
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