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Article

Extracellular ATP induces the proinflammatory phenotype transition of MH7A cells by activating P2X7 receptor.

Purinergic signalling - 3 Mar 2026

Wang Chengxiang, Hao Jiayao, Liu Yan, Shen Haili

Abstract excerpt

The transition of fibroblast-like synoviocytes (FLS) toward a proinflammatory phenotype is a hallmark of rheumatoid arthritis (RA), with proinflammatory RA-FLS exacerbating joint destruction via hyperproliferation, enhanced migration/invasion, and excessive inflammatory cytokine secretion. Extracellular ATP (eATP), a key damage-associated molecular pattern, is elevated in RA's inflammatory microenvironment and...

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Share to Adenosine Triphosphate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41776109
DOI: 10.1007/s11302-026-10138-6
PMCID: PMC12957668

Genes

NLRP3
CCK
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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