Article
Identification and characterization of splice variants of the human P2X7 ATP channel.
Biochemical and biophysical research communications - 24 Jun 2005
Cheewatrakoolpong Boonlert, Gilchrest Helen, Anthes John C, Greenfeder Scott
Abstract excerpt
The P2X7 channel is a member of the P2X family of ligand-gated ion channels which respond to ATP as the endogenous agonist. Studies suggest that P2X7 has a potentially pivotal role in inflammatory responses largely stemming from its role in mediating the release of IL-1beta in response to ATP. We report the identification of seven variants of human P2X7 which result from alternative splicing. Two of these...
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