Article
Transglutaminase type 2-dependent selective recruitment of proteins into exosomes under stressful cellular conditions.
Biochimica et biophysica acta - 1 Aug 2016
Diaz-Hidalgo Laura, Altuntas Sara, Rossin Federica, D'Eletto Manuela, Marsella Claudia, Farrace Maria Grazia, Falasca Laura, Antonioli Manuela, Fimia Gian Maria, Piacentini Mauro
Abstract excerpt
Numerous studies are revealing a role of exosomes in intercellular communication, and growing evidence indicates an important function for these vesicles in the progression and pathogenesis of cancer and neurodegenerative diseases. However, the biogenesis process of exosomes is still unclear. Tissue transglutaminase (TG2) is a multifunctional enzyme with different subcellular localizations. Particularly, under...
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