Article
Multiple Origins of Mutations in the mdr1 Gene--A Putative Marker of Chloroquine Resistance in P. vivax.
PLoS neglected tropical diseases - 1 Nov 2015
Schousboe Mette L, Ranjitkar Samir, Rajakaruna Rupika S, Amerasinghe Priyanie H, Morales Francisco, Pearce Richard, Ord Rosalyn, Leslie Toby, Rowland Mark, Gadalla Nahla B, Konradsen Flemming, Bygbjerg Ib C, Roper Cally, Alifrangis Michael
Abstract excerpt
BACKGROUND: Chloroquine combined with primaquine has been the recommended antimalarial treatment of Plasmodium vivax malaria infections for six decades but the efficacy of this treatment regimen is threatened by chloroquine resistance (CQR). Single nucleotide polymorphisms (SNPs) in the multidrug resistance gene, Pvmdr1 are putative determinants of CQR but the extent of their emergence at population level remains...
Topics
- Antimalarials
- Asia
- Chloroquine
- Drug Resistance
- Ecuador
- Genotype
- Humans
- Microsatellite Repeats
- Multidrug Resistance-Associated Proteins
- Mutation
- Phylogeography
- Plasmodium vivax
- Polymorphism, Single Nucleotide