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Article

Single-nucleotide polymorphism and copy number variation of the multidrug resistance-1 locus of Plasmodium vivax: local and global patterns.

The American journal of tropical medicine and hygiene - 1 Nov 2012

Vargas-Rodríguez Rosa del Carmen Miluska, da Silva Bastos Melissa, Menezes Maria José, Orjuela-Sánchez Pamela, Ferreira Marcelo U

Abstract excerpt

Emerging resistance to chloroquine (CQ) poses a major challenge for Plasmodium vivax malaria control, and nucleotide substitutions and copy number variation in the P. vivax multidrug resistance 1 (pvmdr-1) locus, which encodes a digestive vacuole membrane transporter, may modulate this phenotype. We describe patterns of genetic variation in pvmdr-1 alleles from Acre and Amazonas in northwestern Brazil, and...

Read the complete abstract on PubMed

Topics

Animals
Base Sequence
DNA Copy Number Variations
DNA Primers
Genetic Variation
Multidrug Resistance-Associated Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Plasmodium vivax

Polymerase Chain Reaction

Polymorphism, Single Nucleotide

Protozoan Proteins

Source

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Identifiers

PMID: 22949516
DOI: 10.4269/ajtmh.2012.12-0094
PMCID: PMC3516255

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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