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Article

Genetic diversity and evolutionary perspectives of Pfcrt in Plasmodium falciparum: insights from Indian and global isolates.

Malaria journal - 15 Jun 2026

Narang Geetika, Hawadak Joseph, Jakhan Jahnvi, Singh Vineeta

Abstract excerpt

BACKGROUND: Chloroquine resistance in Plasmodium falciparum (Pf) driven by mutations in the Pf chloroquine resistance transporter (Pfcrt) gene continues to pose a challenge to malaria control in endemic regions like India. Understanding the genetic diversity and evolutionary patterns of Pfcrt is important for guiding malaria surveillance and future national drug policy. METHODS: This study analysed 979 Indian...

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Identifiers

PMID: 42298573
DOI: 10.1186/s12936-026-05974-1
PMCID: PMC13501725

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